Identification of Allosteric Disulfides from Prestress Analysis
نویسندگان
چکیده
منابع مشابه
Identification of allosteric disulfides from labile bonds in X-ray structures
Protein disulfide bonds link pairs of cysteine sulfur atoms and are either structural or functional motifs. The allosteric disulfides control the function of the protein in which they reside when cleaved or formed. Here, we identify potential allosteric disulfides in all Protein Data Bank X-ray structures from bonds that are present in some molecules of a protein crystal but absent in others, o...
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Allostery is a universal phenomenon that couples the information induced by a local perturbation (effector) in a protein to spatially distant regulated sites. Such an event can be described in terms of a large scale transmission of information (communication) through a dynamic coupling between structurally rigid (minimally frustrated) and plastic (locally frustrated) clusters of residues. To el...
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Cell mechanical properties on a whole cell basis have been widely studied, whereas local intracellular variations have been less well characterized and are poorly understood. To fill this gap, here we provide detailed intracellular maps of regional cytoskeleton (CSK) stiffness, loss tangent, and rate of structural rearrangements, as well as their relationships to the underlying regional F-actin...
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The problem of designing prestress to maximize elastic capacity is treated analytically. Our formulation models structures comprised of a one-material elastic continuum, subject to a single deterministic load configuration. The equations needed to predict the optimal prestress design are derived. They are shown to comprise necessary and sufficient conditions for global maximum strength in the u...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2014.06.025